Ancestry and Diversity
Defining and pursuing diversity in human genetic studies, Maili C. Raven-Adams, Tina Hernandez-Boussard, Yann Joly, Bartha Maria Knoppers, Subhashini Chandrasekharan, Judit Kumuthini, Calvin Wai Loon Ho, Ariana Gonzlez, Sarah C. Nelson, Yvonne Bombard, Donrich Thaldar, Hanshi Liu, Alessia Costa, Vijaytha Muralidharan, Sasha Henriques, Jamal Nasir, Aimé Lumaka, Beatrice Kaiser, Saumya Shekhar Jamuar, Anna C. F. Lewis, Nature Genetics, 2024
Getting Genetic Ancestry Right for Science and Society, Anna C. F. Lewis, Santiago J. Molina, Paul S Appelbaum, Bege Dauda, Anna Di Rienzo, Agustin Fuentes, Stephanie M. Fullerton, Nanibaa’ A. Garrison, Nayanika Ghosh, Evelynn M. Hammonds, David S. Jones, Eimear E. Kenny, Peter Kraft, Sandra S.-J. Lee, Madelyn Mauro, John Novembre, Aaron Panofsky, Mashaal Sohail, Benjamin M. Neale, Danielle S. Allen, Science, Vol 376, Issue 6590, pp. 250-252, 2022
- My piece in STAT gives a lay person’s summary: Substituting genetic ancestry for race in research? Not so fast
- And a piece from Matilda Handsley-Davis in COSMOS Magazine: Who’s afraid of genetic ancestry?
- And a piece by Ashley Smart for Undark magazine, A Field at a Crossroads: Genetics and Racial Mythmaking
A scoping review of guidelines for the use of race, ethnicity, and ancestry reveals widespread consensus but also points of ongoing disagreement, Madelyn Mauro, Danielle S. Allen, Bege Dauda, Santiago J. Molina, Benjamin M. Neale, Anna C. F. Lewis, American Journal of Human Genetics, Vol 109, pp2110–2125, 2022
Ancestry: how researchers use it, and what they mean by it, Bege Dauda, Santiago J. Molina, Danielle S. Allen, Agustin Fuentes, Nayanika Ghosh, Madelyn Mauro, Benjamin M. Neale, Aaron Panofsky, Mashaal Sohail, Sarah R. Zhang , Anna C. F. Lewis, Frontiers in Genetics, Vol 14, 2023
An Ethical Framework for Research Using Genetic Ancestry, Anna C. F. Lewis, Santiago J. Molina, Paul S. Appelbaum, Bege Dauda, Agustin Fuentes, Stephanie M. Fullerton, Nanibaa’ A. Garrison, Nayanika Ghosh, Robert C. Green, Evelynn M. Hammonds, Janina M. Jeff, David S. Jones, Eimear E. Kenny, Peter Kraft, Madelyn Mauro, Anil P. S. Ori, Aaron Panofsky, Mashaal Sohail, Benjamin M. Neale, Danielle S. Allen, Perspectives in Biology and Medicine, 2023
Polygenic risk scores
Polygenic risk scores in the clinic: new perspectives needed on familiar ethical issues, A. C. F. Lewis and R. C. Green, 13:14, Genome Medicine, doi: 10.1186/s13073-021-00829-7, 2021
Patient and provider perspectives on polygenic risk scores: implications for clinical reporting and utilization, Anna C. F. Lewis, Emma F. Perez, Anya E. R. Prince, Hana R. Flaxman, Lizbeth Gomez, Deanna G. Brockman, Paulette D. Chandler, Benjamin J. Kerman, Matthew S. Lebo, Jordan W. Smoller, Scott T. Weiss, Carrie L. Blout Zawatksy, James B. Meigs, Robert C. Green, Jason L. Vassy & Elizabeth W. Karlson, Genome Medicine, 14, Article number: 114, 2022
Development of a clinical polygenic risk score assay and reporting workflow, Limin Hao, Peter Kraft, Gabriel F. Berriz, Elizabeth D. Hynes, Christopher Koch, Prathik Korategere V Kumar, Shruti S. Parpattedar, Marcie Steeves, Wanfeng Yu, Ashley A. Antwi, Charles A. Brunette, Morgan Danowski, Manish K. Gala, Robert C. Green, Natalie E. Jones, Anna C. F. Lewis, Steven A. Lubitz, Pradeep Natarajan, Jason L. Vassy & Matthew S. Lebo, Nature Medicine, 2022, https://doi.org/10.1038/s41591-022-01767-6
Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps, Polygenic Risk Score Task Force* of the International Common Disease Alliance, Nature Medicine, 27, p 1876–1884, 2021
Polygenic risk scores in the clinic: Translating risk into action, A C F Lewis, R C Green, J L Vassy, HGG Advances, 2 (4), 2021
Managing differential performance of polygenic risk scores across groups: Real-world experience of the eMERGE Network, Anna C.F. Lewis, Rex L. Chisholm, John J. Connolly, Edward D. Esplin, Joe Glessner, Adam Gordon, Robert C. Green, Hakon Hakonarson, Margaret Harr, Ingrid A. Holm, Gail P. Jarvik, Elizabeth Karlson, Eimear E. Kenny, Leah Kottyan, Niall Lennon, Jodell E. Linder, Yuan Luo, Lisa J. Martin, Emma Perez, Megan J. Puckelwartz, Laura J. Rasmussen-Torvik, Maya Sabatello, Richard R. Sharp, Jordan W. Smoller, Rene Sterling, Shannon Terek, Wei-Qi Wei, and Stephanie M. Fullerton, AJHG, https://doi.org/10.1016/j.ajhg.2024.04.005, 2024
Genetic discrimination
The Problems with Patchwork: State Approaches to Regulating Insurer Use of Genetic Information, J. Anderson, A. C. F. Lewis, A. E. R. Prince, DePaul Journal of Health Care Law, 2(1), 2021
Long-awaited progress in addressing genetic discrimination in the United States, A. C. F. Lewis, R. C. Green & A. E. R. Prince, Genetics in Medicine, 2020
CRISPR
Regulating Genetic Advantage, S Polcz, A Lewis, Harvard Journal of Law & Technology, 32 (1), 265-297, 2018
- Should we regulate genetic advantage? (a blog piece)
A Menagerie of Moral Hazards: Regulating Genetically Modified Animals, S. Polcz, A Lewis, Journal of Law and Medical Ethics, 46 (1), 180-184, 2018 (Available on SSRN here)
CRISPR-Cas9 and the Non-Germline Non-Controversy, S Polcz, A Lewis, Journal of Law and the Biosciences 3, 413, 2016
Other ELSI
An international policy on returning genomic research results, Anna C F Lewis, Bartha Maria Knoppers, Robert C Green, Genome Medicine, 13 (115), 2021
AI Ethics
Where Bioethics Meets Machine Ethics, Anna C. F. Lewis, American Journal of Bioethics, 20:11, 22-24, DOI: 10.1080/15265161.2020.1819471, 2020
Compassionate Machines: The Ethics of “Artificial Empathy” in Cancer Care, Erica Koranteng, Anna C. F. Lewis, Gregory A. Abel, JAMA Oncology, doi:10.1001/jamaoncol.2024.0824, 2024
Multi-Value Alignment for ML/AI development choices: a four-step process including approaches to trade-offs, Hetvi Jethwani and Anna C F Lewis, American Philosophical Quarterly, 62 (2): 133–152, 2025
Blogs
A Narrow Path for Optimism that Social Genomics Can Combat Inequality, Bioethics Forum, Nov 23 2020
Caster Semenya’s case gives a concrete opportunity to challenge the binary
Gay genes, liberals, and the relevance of biology to politics
A few opinion pieces from my All The Coolest Genomics blog
- What next for human germline editing?
- Some thoughts on the recommendation to “proceed with caution” on human germline modification
- Lulu and Nana: the children who will help change our morals
- Our posthuman future
Podcasts
The Genetics Podcast, https://thegeneticspodcast.fireside.fm/67, “EP67: Dr Anna Lewis from the Edmond J. Safra Center for Ethics at Harvard, on the biggest ethical questions in DNA sequencing and editing”
Channel Africa’s African Dialogue, “Artificial Intelligence in the Health sector”, https://omny.fm/shows/african-dialogue/artificial-intelligence-in-the-health-sector
Genetically Speaking, “Addressing genetic discrimination in the USA”, https://learning.ashg.org/products/paper-chat-addressing-genetic-discrimination-in-the-usa
Other papers
I have published various science papers, list available on my google scholar page.
Anna C F Lewis 